[Hemorheological indices in patients with amebic abscesses of the liver and their correction]. / Gemoreologicheskie pokazateli u bol'nykh s amebnymi abstsessami pecheni i ikh korrektsiia.

Hemorheological indices were studied in 89 patients. In 61 patients the authors have revealed somewhat increased viscosity potential of blood and negligible changes in the aggregation activity of erythrocytes which is thought by the authors to be due to the saved compensatory potentialities of the organism. In 28 patients with the complicated course of the disease the rheological parameters of blood became worse because of the suppressed compensatory potentialities of organism. So, in addition to the adequate transfusion-infusion therapy the complex of treatment must include immunostimulating means (Levamisole, Prodigiozan, Tactivin etc.).

[The use of prodigiozan in the combined therapy of the sequelae of mild craniocerebral trauma]. / Primenenie prodigiozana v kompleksnoi terapii posledstvii legkoi cherepno-mozgovoi travmy.

Based on findings secured with the aid of instrumental and immunological techniques (electroencephalography, echoencephalography, roentgenoencephalography) a total of 57 patients with sequelae of mild craniocerebral injury were examined. Used in the study as an immunomodulating agent was prodigiosan. The drug was found to improve the bioelectrical activity of the brain, and to increase the amplitude of blood filling as evidenced by neurophysiological investigations. Moreover, prodigiosan makes for reduction of vegetovascular disorders and epileptic seizures, returning the level of neurospecific proteins to normal.

[Stimulation of regenerative processes and correction of the functional activity of the liver in its partial resection and toxic lesions]. / Stimuliatsiia protsessov regeneratsii i korrektsiia funktsional'noi aktivnosti pecheni pri ee chastichnoi rezektsii i toksicheskikh porazheniiakh.

The effects of hepatotropic growth factors (HGFs) and phospholipid drugs on the recovery of functions and the regeneration of the rat liver were studied in CC14-induced toxic damage and after partial hepatectomy (PHE). HGFs isolated from the cytoplasmic cells of the regenerating liver, as well as from the liver of the animals given prodigiozan and from the media taken after culturing the explants of the regenerating liver were found to stimulate DNA synthesis and hepatocytic proliferation following PHE and in the cirrhotic liver. Prodigiozan was shown to induce the formation of HGFs not only in the rat liver following PHE, but in the liver of intact animals. It was established that the covalently binding complex of albumin and bilirubin stimulated the synthesis of proteins and DNA in the regenerating liver, but non-covalently binding complex inhibited these processes. When CC14 was administered to the animals, the two complexes enhanced the reparative synthesis of DNA, without changing the level of replicating synthesis, the non-covalently binding complex completely eliminating the single-strand breaks in DNA. Phospholipid agents containing soybean and sunflower phosphatidylcholines increased the synthesis of RNA and albumin, which were decreased due to exposure to CC14 and had the property of stimulating the synthesis of total DNA and considerably enhancing that of mitochondrial DNA.

[Prodigiozan modulation of the specific activity of antidepressants]. / Moduliatsiia prodigiozanom spetsificheskoi aktivnosti antidepressantov.

The experiments carried out on mongrel male mice showed that bacterial lipopolysaccharide Prodigiozan inhibit the activity of P-450-dependent monooxygenases of the liver, thus changing the activity of antidepressants--amitriptyline and imipraminum. The data on biological activity were tested in "tail suspension" test. Prodigiozan exhibited no central effect. Changes in biotransformation processes after single administration of both drugs resulted in the delay and prolongation of the effect. Prodigiozan prevents the induction of microsomal enzymes caused by antidepressants. Amitriptyline do not affect the immunostimulating action of prodigiozan, whereas imipraminum inhibited prodigiozan activity.

[Correction of immunologic disorders in patients with chronic suppurative otitis media]. / Korrektsiia immunologicheskikh narushenii u bolnykh khronicheskim gnoinym srednim otitom.

The absolute and relative content of T- and B-lymphocytes, T-helpers (CD4), T-suppressors (CD8), phagocytosis, complement and immunoglobulins A, M, G in the blood serum was examined in patients with chronic purulent otitis media. The investigation also involved tests on immunological activity of tymoptin (T), sodium nucleinate (SN), prodigiosan (PR), the combination of SN with PR. 148 patients aged 15-56 years were subdivided into 5 groups. In pretreatment immunological status of all the patients the count of T- and B-lymphocytes, T-helpers, phagocytosis were reduced against increased counts of IgM and T-suppressora. All the patients received similar conventional treatment with adjuvant SN (group 2), PR (group III), SN + PR (group 4), T (group 5). The conventional conservative and especially surgical treatment aggravated immunodeficiency. The adjuvant immunocorrectors potentiated the treatment effects which appeared to be most beneficial in group V followed by by groups IV, II and III in diminishing order.

[Effect of bacterial preparations on the hematopoiesis of irradiated animals]. / Vliianie bakterial'nykh preparatov na gemopoéz obluchennykh zhivotnykh.

It was shown in experiments with mice and dogs that bacterial preparations (vaccinum proteus, prodigiosanum, bificolum and bificolum-f) administered before or after gamma-irradiation have a stimulating effect on hemopoiesis. It is supposed that bacterial polysaccharides play an important role in this action.

[Doxycycline in the combined treatment of the tuboperitoneal form of infertility of chlamydial etiology (a clinico-endoscopic study)]. / Doksitsiklin v kompleksnom lechenii trubno-peritoneal'noi formy besplodiia khlamidiinoi étiologii (kliniko-édoskopicheskoe issledovanie).

The diagnostic laparoscopy revealed ascending multifocal affections of the chlamydial origin in the organs of the small pelvis. It provided an objective information on the tuboperitoneal inflammation and made it possible to apply the adequate treatment. The surgical laparoscopy (adhesiotomy and salpingostomy) in the comprehensive treatment with the use of doxycycline and prodigiosan promoted the recovery of the female reproductive function.

[The effect of different types of immunocorrective therapy on the clinical course of chronic myeloleukemia]. / Vliianie razlichnykh vidov immunokorrigiruiushchei terapii na klinicheskoe techenie khronicheskogo mieloleikoza.

Influence of various patterns of immunocorrective therapy on clinical course of chronic myeloleukemia (CML) was studied. It was shown that combinations of drugs with different pharmacological effects provide more than 5-fold decrease in incidence of infection-related complications and promote rapid recovery from infections during antibacterial treatment.

[The clinico-immunological efficacy of paspat and prodigiozan in the combined treatment of infectious-allergic bronchial asthma]. / Kliniko-immunologicheskaia éffektivnost' paspata i prodigiozana v kompleksnom lechenii infektsionno-allergicheskoi bronkhial'noi astmy.

64 patients with infectious-allergic bronchial asthma (IABA) were examined. 20 of them were co-administered paspat, 24 patients additionally received prodigiosan, 20 patients constituted control group and were given conventional treatment. Patients of all the groups were comparable in age, state of immunological reactivity of the body and severity of the disease. Immunomodulatory effect of the drugs, mainly of paspat, not only resulted in normalization of functional properties of granulocytes but also promoted liquidation of quantitative and functional IABA-conditioned immunodeficiency on the part of T- and B-lymphocytes, thus increasing effectiveness of the treatment in the whole.

[The use of preparations of protozoan origin as agents for the prevention and early therapy of combined radiation-thermal injuries]. / Ispol'zovanie preparatov protozoinogo proiskhozhdeniia v kachestve sredstv profilaktiki i rannei terapii kombinirovannykh radiatsionno-termicheskikh porazhenii.

Radioprotective and therapeutic effects of astazian and astazilide, the drugs of protozoan origin, were studied in comparison with known modifiers of biological reactions (bacterial polysaccharides, synthetic polypeptides) in combined radiation-thermal injuries (CRTI). The efficiency of drugs under examination was found to be time- and dose-dependent. Application of the drugs of protozoan nature 24 hours prior to or 1 hour following CRTI provided 30 to 50% survival of experimental animals for 30 days as compared to 4.5% in the group of untreated mice. Administration of the drugs 3-7 days following CRTI exerted no therapeutic effect.

[Therapeutic tactics in the association of acute cholecystitis and obesity]. / Lechebnaia taktika pri sochetanii ostrogo kholetsistita s ozhireniem.

From experience in the treatment of 326 patients with acute cholecystitis and concomitant obesity the authors discuss the causes of unfavourable outcomes and plan the means for improving the results. Postoperative suppuration of the wound occurred in 31.5% of cases, and was encountered most frequently in patients who underwent emergency and urgent operations. It was established that concomitant obesity in patients with acute cholecystitis is a factor raising the risk of postoperative pyo-inflammatory complications. The immune status was found to be significantly depressed. Preoperative immunoprophylaxis should be applied to prevent pyo-inflammatory complications after the operation.

[Reaferon and interferonogenes in the therapy of acute viral hepatitis B]. / Primenenie reaferona i interferonogenov v terapii ostrogo virusnogo gepatita B.

Monotherapy with reaferon (alpha 2-interferon) versus prodigiosan plus ibuprofen combination was investigated in acute viral hepatitis B. The drugs were found to stimulate cellular immunity and to induce a decrease of total serum IgE levels. The effect of prodigiosan combined with ibuprofen proved more pronounced.

[Changes in cytotoxicity of natural killer cells and level of large granule-containing lymphocytes in patients with lung cancer under the effects of cryosurgery]. / Izmenenie tsitotoksichnosti estestvennykh killerov i urovnia bol'shikh granulosoderzhashchikh limfotsitov u bol'nykh rakom legkogo pod vliianiem kriokhirurgii.

The parallel study of the content of large granule-containing lymphocytes (LGL) and natural killer activity (NKA) in donors, patients with benign tumors in the lungs and bronchial or pulmonary cancer in operative intervention and combined cryosurgical treatment was carried out. The stimulating effect of cryodestruction of malignant tumors with their subsequent spontaneous thawing on LGL content and NKA in patients was established. Administration of prodigiosan immunomodulator contributed to increase in natural resistance of an organism of the patients. The positive correlation of NKA and LGL content was noted.

[The pharmacokinetic and immunopharmacological aspects of prodigiozan interaction with psychotropic agents]. / Farmakokineticheskie i immunofarmakologicheskie aspekty vzaimodeistviia prodigiozana s psikhotropnymi sredstvami.

In experiments on white male mice it was found that an immunostimulant prodigiozan suppresses the activity of cytochrome P-450-dependent liver monohygenases that results in modulation of the activity of neuroleptics (aminazine and haloperidol) administered against its background. Their activity is assessed by the "open field "test" and the "tail suspension test". One could observe a delay of the occurrence of the neuroleptics' effect and prolongation of the effect. Acute toxicity of aminazine was shown to decrease. The changes are most probably due to a slowing of metabolism of the neuroleptics in the liver. On the other hand, administration of neuroleptics against the background of prodigiozan fails to affect its immunostimulating effect despite diverse influences of the drugs on the activity of the liver monooxygenase.

[The effect of antibiotics and immunostimulants on rickettsial persistence in experimental typhus infection]. / Vliianie antibiotikov i immunostimuliatorov na persistirovanie rikketsii pri éksperimental'noi sypnotifoznoi infektsii.

A model of experimental typhus infection has shown that not only specific protection factors but also nonspecific ones are very important to remove Rickettsia prowazekii from macroorganisms. A complex application of antibiotics and drugs increasing immunobiological reactivity of the organism (prodigiosan, methyl uracil) noticeably decreases the rickettsia persistence level in the organism of experimental animals, the indices of specific and nonspecific protection being increased.

[The effect of immunostimulants on the resistance of white mice to the causative agent of typhoid fever]. / Izuchenie vliianiia immunostimuliatorov na ustoichivost' belykh myshei k vobuditeliu briushnogo tifa.

The influence of prodigiosan, salmosan, polyribonate and levamisole on the body nonspecific and specific resistance to S. typhi strain 4446 has been studied. Prodigiosan and salmosan have proved to be the most effective. The injection of these compounds simultaneously with typhoid vaccine (both chemical adsorbed vaccine and alcohol-treated vaccine, enriched with Vi-antigen) significantly increases the survival rate of immunized animals (by 35-45%), elevates the resistance index (1.5- to 2.3-fold) and the effectiveness index of the vaccine (17- to 32-fold) in comparison with the controls. Besides, prodigiosan and salmosan alone are capable of increasing nonspecific resistance to S. typhi strain 4446, which is manifested by an increase of the survival rate of stimulated animals by 61.87%. Proceeding from the results thus obtained, the possibility of good prospects for prodigiosan and salmosan in the prophylaxis of typhoid fever in humans may be inferred.